The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2018
Filed:
Sep. 28, 2013
Applicants:
Shanghai Genon Bioengineering Co., Ltd, Shanghai, CN;
Shanghai Transgenic Research Center, Shanghai, CN;
Inventors:
Assignees:
SHANGHAI GENON BIOENGINEERING CO., LTD, Shanghai, CN;
SHANGHAI TRANSGENIC RESEARCH CENTER, Shanghai, CN;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C07H 21/04 (2006.01); C12N 15/90 (2006.01); A01K 67/027 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); A01K 67/0275 (2013.01); C12N 15/8509 (2013.01); A01K 2217/072 (2013.01); A01K 2227/102 (2013.01); A01K 2267/03 (2013.01); C12N 2800/30 (2013.01); C12N 2800/80 (2013.01);
Abstract
Provided in the present invention is a method for positioning and integrating transgene and a use thereof. Specifically provided is a variant loxP element. The sequence 'ATAAT' of an reverse repeated sequence in a wild type loxp locus is mutated into 'CACCT', i.e., a variant loxp element. Also provided in the present invention are a construct comprising the variant loxP element, a vector or host cell comprising the construct and a method for preparing a transgenic animal using the vector and the host cell.