The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2018
Filed:
Aug. 23, 2017
Applicant:
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Inventors:
Grant D. Trobridge, Lake Forest Park, WA (US);
Hans-Peter Kiem, Seattle, WA (US);
Assignee:
FRED HUTCHINSON CANCER RESEARCH CENTER, Seattle, WA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); A61K 39/12 (2006.01); A61K 39/205 (2006.01); C12N 15/86 (2006.01); C12N 7/00 (2006.01); A61K 35/28 (2015.01); C07K 14/005 (2006.01); A61K 35/12 (2015.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 35/28 (2013.01); C07K 14/005 (2013.01); A61K 48/00 (2013.01); A61K 2035/124 (2013.01); C12N 2740/16043 (2013.01); C12N 2740/16045 (2013.01); C12N 2760/20222 (2013.01); C12N 2760/20243 (2013.01); C12N 2810/6081 (2013.01);
Abstract
Provided herein are Cocal vesiculovirus envelope pseudotyped retroviral vectors that exhibit high titers, broad species and cell-type tropism, and improved serum stability. Disclosed Cocal vesiculovirus envelope pseudotyped retroviral vectors may be suitably employed for gene therapy applications and, in particular, for the ex vivo and in vivo delivery of a gene of interest to a wide variety of target cells.