The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2018
Filed:
Sep. 19, 2014
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Washington, DC (US);
Inventors:
Laura B. Jaeger, North Bethesda, MD (US);
Avindra Nath, Ellicott City, MD (US);
Eugene Major, Darnestown, MD (US);
Maria Chiara Kushner-Monaco, Kensington, MD (US);
Michael W. Ferenczy, Washington, DC (US);
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7115 (2006.01); A61K 31/712 (2006.01); A61K 31/7125 (2006.01); C12N 15/113 (2010.01); C07K 16/08 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1131 (2013.01); C07K 16/084 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/346 (2013.01); C12N 2710/22011 (2013.01);
Abstract
The instant invention provides compositions and methods for inhibiting the JC Virus (JCV), and that can be used, for example, for treating progressive multifocal leukoencephalopathy (PML). Antisense oligonucleotides are provided which are effective in inhibiting JCV replication or multiplication, alone or in a combination. In preferred embodiments, the oligonucleotides contain modifications.