The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 31, 2018

Filed:

Jun. 02, 2017
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);

Inventors:

Peter D. Kwong, Washington, DC (US);

Gary J. Nabel, Cambridge, MA (US);

Rebecca S. Rudicell, Silver Spring, MD (US);

John Mascola, Rockville, MD (US);

Mark Connors, Bethesda, MD (US);

Ivelin Georgiev, Nashville, TN (US);

Jiang Zhu, Ashburn, VA (US);

Young Do Kwon, Rockville, MD (US);

Tongqing Zhou, Boyds, MD (US);

Yongping Yang, Potomac, MD (US);

Baoshan Zhang, Bethesda, MD (US);

Gwo-Yu Chuang, Rockville, MD (US);

Xueling Wu, Potomac, MD (US);

Zhi-yong Yang, Potomac, MD (US);

Wei Shi, Rockville, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/10 (2006.01); G01N 33/569 (2006.01); A61K 39/42 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1063 (2013.01); A61K 39/42 (2013.01); A61K 45/06 (2013.01); G01N 33/56983 (2013.01); G01N 33/56988 (2013.01); C07K 2317/21 (2013.01); C07K 2317/41 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/72 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.


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