The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2018
Filed:
Aug. 10, 2015
Applicant:
Delinia, Inc., Cambridge, MA (US);
Inventor:
Jeffrey Greve, Berkeley, CA (US);
Assignee:
Delinia, Inc., Emeryville, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); C07K 14/55 (2006.01); A61K 47/48 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/55 (2013.01); A61K 38/2013 (2013.01); A61K 47/48215 (2013.01); A61K 38/00 (2013.01);
Abstract
The invention described herein is a novel IL-2 protein with selective agonist activity for Regulatory T cells and with an additional amino acid substitution that enable chemical conjugation with Polyethyene Glycol (PEG) that increase circulating half-life compared to the IL-2 selective agonist alone. A preferred IL-2 selective agonist variant is IL2/N88R/C125S/D109C.