The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 31, 2018

Filed:

Jun. 18, 2009
Applicants:

Darwin J. Prockop, Philadelphia, PA (US);

Ryanghwa Lee, Round, TX (US);

Inventors:

Darwin J. Prockop, Philadelphia, PA (US);

RyangHwa Lee, Round, TX (US);

Assignee:

The Texas A&M University System, College Station, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); C07K 14/435 (2006.01); C07K 14/525 (2006.01); C12N 5/0775 (2010.01);
U.S. Cl.
CPC ...
C07K 14/525 (2013.01); C12N 5/0663 (2013.01); C12N 2501/25 (2013.01); C12N 2501/585 (2013.01);
Abstract

The present invention provides compositions comprising mesenchymal stem cells (MSCs), and methods for their novel use in the repair of cardiac damage and treatment of inflammatory diseases. The invention also provides methods for using TSG-6 protein that is secreted by MSCs under certain conditions, for repair of cardiac damage and inflammatory disease. The compositions of the invention may be particularly useful in restoring cardiac function following cardiac damage, including, but not limited to, myocardial infarction, as well as in reducing symptoms of inflammatory disease.


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