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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10035809 B1

PDFFull Text
Date of Patent:
Jul. 31, 2018

Filed:

May. 18, 2017

Substituted 2,3,4,5,7,9,13,13a-octahydro-1,5-methanopyrido[1',2′:4,5]pyrazino[1,2-a][1,3]diazepines and methods for treating viral infections

Applicant:

Gilead Sciences, Inc., Foster City, CA (US);

Inventors:

Elizabeth M. Bacon, Burlingame, CA (US);

Zhenhong R. Cai, Palo Alto, CA (US);

Xiaowu Chen, Hillsborough, CA (US);

Jeromy J. Cottell, Redwood City, CA (US);

Manoj C. Desai, Foster City, CA (US);

Mingzhe Ji, Union City, CA (US);

Haolun Jin, Foster City, CA (US);

Scott E. Lazerwith, Burlingame, CA (US);

Michael R. Mish, Foster City, CA (US);

Philip Anthony Morganelli, Oakland, CA (US);

Hyung-Jung Pyun, Fremont, CA (US);

James G. Taylor, Burlingame, CA (US);

Teresa Alejandra Trejo Martin, Belmont, CA (US);

Assignee:

GILEAD SCIENCES, INC., Foster City, CA (US);

Attorney:
Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
A61K 31/4985 (2006.01); C07D 487/04 (2006.01); C07D 498/14 (2006.01); A61K 31/537 (2006.01); C07D 471/22 (2006.01); A61K 31/529 (2006.01); A61K 31/551 (2006.01); A61K 31/553 (2006.01); C07D 471/18 (2006.01); A61K 45/06 (2006.01); C07D 498/18 (2006.01); C07D 487/14 (2006.01); A61K 31/498 (2006.01);
U.S. Cl.
CPC ...
C07D 498/14 (2013.01); A61K 31/498 (2013.01); A61K 31/529 (2013.01); A61K 31/537 (2013.01); A61K 31/551 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 471/18 (2013.01); C07D 471/22 (2013.01); C07D 487/14 (2013.01); C07D 498/18 (2013.01);
Abstract

Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, X, W, Y, Y, Z, and Zare as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

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