The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 31, 2018

Filed:

Mar. 13, 2014
Applicants:

Constellation Pharmaceuticals, Inc., Cambridge, MA (US);

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Brian K. Albrecht, Cambridge, MA (US);

Steven F. Bellon, Wellesley, MA (US);

Victor S. Gehling, Somerville, MA (US);

Jean-Christophe Harmange, Andover, MA (US);

Kwong Wah Lai, Shanghai, CN;

Jun Liang, South San Francisco, CA (US);

Peter Dragovich, South San Francisco, CA (US);

Daniel F. Ortwine, South San Francisco, CA (US);

Sharada Labadie, South San Francisco, CA (US);

Birong Zhang, South San Francisco, CA (US);

James Richard Kiefer, South San Francisco, CA (US);

Assignees:

GENENTECH, INC., South San Francisco, CA (US);

CONSTELLATION PHARMACEUTICALS INC., Cambridge, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 31/5377 (2006.01); A61K 31/337 (2006.01); A61K 31/517 (2006.01); A61K 31/437 (2006.01); C12N 9/99 (2006.01); C07D 498/04 (2006.01); C07D 487/14 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/337 (2013.01); A61K 31/437 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 487/14 (2013.01); C07D 498/04 (2013.01); C12N 9/99 (2013.01);
Abstract

Provided are compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using the present composition in the treatment of various disorders.


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