The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2018
Filed:
Feb. 12, 2015
Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, Zhejiang, CN;
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
Fuli Zhang, Shanghai, CN;
Zhezhou Yang, Shanghai, CN;
Rusheng Bao, Taizhou, CN;
Weiwei Xu, Taizhou, CN;
Hua Bai, Taizhou, CN;
Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, Zhejiang, CN;
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
Abstract
Disclosed is a preparation method for praziquantel and intermediates thereof. The method includes: obtaining a target product praziquantel by using β-phenethylamine as an initial raw material through a condensation reaction with chloroacetyl chloride, a substitution reaction with ethanolamine, and an acylation reaction with cyclohexanecarbonyl chloride, followed by an oxidation reaction and cyclization reaction. Also disclosed are two key intermediates, namely, a compound of formula IV and a compound of formula V for preparing praziquantel. The preparation method is reasonable and simple in its technological design, uses moderate reaction conditions, and is economical and environmentally friendly. Additionally, the raw materials are inexpensive and easy to obtain, the key intermediates are easy to prepare, and the total reaction yield and purity of the obtained target compound praziquantel is high, so that industrialized mass production is easy to achieve.