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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10034886 B1

PDFFull Text
Date of Patent:
Jul. 31, 2018

Filed:

Sep. 21, 2017

Glp-1 receptor modulators

Applicant:

Celgene International Ii Sàrl, Couvet, CH;

Inventors:

Marcus F. Boehm, San Diego, CA (US);

Esther Martinborough, San Diego, CA (US);

Manisha Moorjani, San Diego, CA (US);

Junko Tamiya, Carlsbad, CA (US);

Liming Huang, San Diego, CA (US);

Adam R. Yeager, La Mesa, CA (US);

Enugurthi Brahmachary, San Diego, CA (US);

Thomas Fowler, Melton Mowbray, GB;

Andrew Novak, Long Eaton, GB;

Premji Meghani, Loughborough, GB;

Michael Knaggs, Burton-on-Trent, GB;

Daniel Glynn, Sneinton, GB;

Mark Mills, Carlton, GB;

Assignee:

Celgene International II SÀRL, Couvet, CH;

Attorney:

Seed IP Law Group LLP

Primary Examiner:

Deepak R Rao

Int. Cl.
CPC ...
A61K 31/506 (2006.01); C07D 403/10 (2006.01); A61K 31/551 (2006.01); A61K 31/4725 (2006.01); A61K 31/495 (2006.01); A61K 31/4545 (2006.01); A61K 31/454 (2006.01); A61K 31/4468 (2006.01); A61K 31/4439 (2006.01); A61K 31/445 (2006.01); A61K 31/44 (2006.01); A61K 31/433 (2006.01); A61K 31/4245 (2006.01); A61K 31/426 (2006.01); A61K 31/421 (2006.01); A61K 31/4178 (2006.01); C07D 495/04 (2006.01); C07D 471/04 (2006.01); A61K 31/402 (2006.01); C07D 417/12 (2006.01); C07D 413/12 (2006.01); C07D 413/04 (2006.01); C07D 409/14 (2006.01); C07D 409/12 (2006.01); C07D 407/12 (2006.01); C07D 405/12 (2006.01); C07D 403/12 (2006.01); C07D 403/04 (2006.01); C07D 401/12 (2006.01); C07D 401/06 (2006.01); C07D 401/04 (2006.01); C07D 295/135 (2006.01); C07D 295/084 (2006.01); C07D 285/12 (2006.01); C07D 285/08 (2006.01); C07D 277/30 (2006.01); C07D 271/107 (2006.01); C07D 271/06 (2006.01); C07D 263/32 (2006.01); C07D 253/065 (2006.01); C07D 253/06 (2006.01); C07D 243/08 (2006.01); C07D 241/12 (2006.01); C07D 241/08 (2006.01); C07D 239/74 (2006.01); C07D 239/34 (2006.01); C07D 239/26 (2006.01); C07D 237/08 (2006.01); C07D 231/12 (2006.01); C07D 215/14 (2006.01); C07D 213/55 (2006.01); C07D 211/98 (2006.01); C07D 211/22 (2006.01); C07D 207/08 (2006.01); A61K 38/26 (2006.01); A61K 31/53 (2006.01); A61K 31/505 (2006.01); A61K 31/501 (2006.01); A61K 31/50 (2006.01); A61K 31/4965 (2006.01); A61K 31/497 (2006.01); A61K 31/4709 (2006.01);
U.S. Cl.
CPC ...
A61K 31/551 (2013.01); A61K 31/402 (2013.01); A61K 31/4178 (2013.01); A61K 31/421 (2013.01); A61K 31/426 (2013.01); A61K 31/4245 (2013.01); A61K 31/433 (2013.01); A61K 31/44 (2013.01); A61K 31/445 (2013.01); A61K 31/4439 (2013.01); A61K 31/4468 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/495 (2013.01); A61K 31/497 (2013.01); A61K 31/4965 (2013.01); A61K 31/50 (2013.01); A61K 31/501 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/53 (2013.01); A61K 38/26 (2013.01); C07D 207/08 (2013.01); C07D 211/22 (2013.01); C07D 211/98 (2013.01); C07D 213/55 (2013.01); C07D 215/14 (2013.01); C07D 231/12 (2013.01); C07D 237/08 (2013.01); C07D 239/26 (2013.01); C07D 239/34 (2013.01); C07D 239/74 (2013.01); C07D 241/08 (2013.01); C07D 241/12 (2013.01); C07D 243/08 (2013.01); C07D 253/06 (2013.01); C07D 253/065 (2013.01); C07D 263/32 (2013.01); C07D 271/06 (2013.01); C07D 271/107 (2013.01); C07D 277/30 (2013.01); C07D 285/08 (2013.01); C07D 285/12 (2013.01); C07D 295/084 (2013.01); C07D 295/135 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 495/04 (2013.01);
Abstract

Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where '' represents either or both the R and S form of the compound): where A, B, C, Y, Y, Z, R, R, R, R, R, W, n, p and q are as defined herein.

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