The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10031143 B1

PDF
Full Text
Expired
Date of Patent:
Jul. 24, 2018

Filed:

May. 21, 2015
Applicants:

Reclaimrx, Llc, Bloomington, IN (US);

University of Massachusetts, Boston, MA (US);

Eric M. Graban, Bloomington, IN (US);

Richard Vachet, Belchertown, MA (US);

Inventors:

Eric M. Graban, Bloomington, IN (US);

Richard Vachet, Belchertown, MA (US);

Yuping Zhou, Carmel, IN (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6848 (2013.01); G01N 2560/00 (2013.01);
Abstract

Some aspects of the disclosure include methods for comparing the higher order structures (HOS) of proteins using covalent labeling agents which allow for the direct comparison of changes in the HOS of protein therapeutics using mass spectrometry. The inventive methods can be used to access the effect of changing the process of producing and/or storing complex biologic compounds as well as determining if the HOS of a protein therapeutic has spontaneously changed during storage. Still other uses include comparing branded biologic therapeutic compounds to biosimilar compounds, and measuring changes in the aggregation states of proteins.


Find Patent Forward Citations

Graban, Eric. (2018). Method for the comparison of protein higher order structures (U.S. Patent No. 10031143). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10031143

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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