The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2018
Filed:
Jul. 17, 2015
Zhejiang University, Hangzhou, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
Abstract
Implementations herein relates to a biological sample signal amplification method using terahertz metamaterials and gold nanoparticles. A plurality of biological sample solutions and a plurality of gold nanoparticles-labeled avidin solutions are dropped on surfaces of metamaterials and dried at room temperature. Terahertz time-domain signals of sample points and reference sample points on the surfaces of metamaterials are acquired, transmission or reflectance of the sample points and the reference sample points are calculated using terahertz time-domain signals, and the frequency shift of transmission or reflection peaks are calculated according to the lowest point of transmission or reflectance. The effect of local electric field enhancement of metamaterials is used for sample signal amplification, gold nanoparticles are used to change a distribution of electric fields, and a sample signal is further enhanced by gold nanoparticles modification.