The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 24, 2018

Filed:

Aug. 05, 2014
Applicant:

Northeastern University, Boston, MA (US);

Inventors:

Jin Young Lee, Seoul, KR;

Ahmed Busnaina, Needham, MA (US);

Hanchul Cho, Gyeonggi-do, KR;

Sivasubramanian Somu, Natick, MA (US);

Assignee:

Northeastern University, Boston, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/00 (2006.01); G01N 33/00 (2006.01); G01N 27/414 (2006.01); C12Q 1/58 (2006.01); C12Q 1/00 (2006.01); B82Y 15/00 (2011.01); C12Q 1/26 (2006.01); C12Q 1/54 (2006.01); H01L 29/40 (2006.01); G01N 27/12 (2006.01);
U.S. Cl.
CPC ...
G01N 27/4146 (2013.01); B82Y 15/00 (2013.01); C12Q 1/005 (2013.01); C12Q 1/006 (2013.01); C12Q 1/26 (2013.01); C12Q 1/54 (2013.01); C12Q 1/58 (2013.01); H01L 29/401 (2013.01); G01N 27/127 (2013.01);
Abstract

A single-walled carbon nanotube-based micron scale multiplex biosensor is provided that enables the detection of glucose, lactate, and urea. The sensor is based on modification of semiconducting single-walled carbon nanotubes using a linker that non-covalently associates with the nanotubes and covalently couples to an enzyme. Reaction of a physiological substrate with the enzyme results in increased resistance of the nanotubes within the sensor. The sensor is suitable for use in patient monitoring, particularly in a clinical setting. Incorporation of read out electronics and an RF signal generator into the sensor device enables it to communicate to a relay station or remote receiver. Methods are also provided for fabricating the biosensor device and using the device for detection.


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