The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2018
Filed:
Oct. 31, 2013
Applicant:
Ipsen Bioinnovation Ltd., Abingdon, Oxfordshire, GB;
Inventors:
Assignees:
IPSEN BIOINNOVATION LIMITED, Abingdon, Oxfordshire, GB;
IPSEN BIOPHARM LIMITED, Slough, Berkshire, GB;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/52 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); C12Y 304/24069 (2013.01); A61K 38/00 (2013.01);
Abstract
The invention provides a nucleic acid sequence comprising a sequence of contiguous nucleotides, wherein said sequence of contiguous nucleotides has at least 90% sequence identity to the nucleic acid sequence of SEQ ID NO: 1, and wherein said sequence of contiguous nucleotides encodes a single-chain BoNT/E1 protein. The present invention also provides methods for producing soluble single-chain BoNT/E1 protein in anhost cell, together with methods for producing soluble di-chain BoNT/E1 protein.