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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10030234 B1

PDFFull Text
Date of Patent:
Jul. 24, 2018

Filed:

Sep. 07, 2016

Modified gram positive bacteria and uses thereof

Applicant:

Intrexon Actobiotics NV, Zwijnaarde, BE;

Inventors:

Lothar Steidler, Lokeren, BE;

Karolien Van Huynegem, Asper, BE;

Klaas Vandenbroucke, De Pinte, BE;

Assignee:

INTREXON ACTOBIOTICS NV, Zwijnaarde, BE;

Attorney:

Drinker Biddle & Reath LLP

Primary Examiner:

Gary B Nickol

Assistant Examiner:

Lakia J Jackson-Tongue

Int. Cl.
CPC ...
A01N 63/00 (2006.01); A61K 39/02 (2006.01); A01N 63/02 (2006.01); C12N 1/20 (2006.01); C12N 1/00 (2006.01); C12N 9/10 (2006.01); A61K 35/744 (2015.01); C12N 1/04 (2006.01); C12N 15/74 (2006.01); A23L 33/135 (2016.01); C12P 19/12 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); C07K 14/325 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1051 (2013.01); A23L 33/135 (2016.08); A61K 35/744 (2013.01); C12N 1/04 (2013.01); C12N 1/20 (2013.01); C12N 15/746 (2013.01); C12P 19/12 (2013.01); C12Y 204/01216 (2013.01); A23V 2002/00 (2013.01); A61K 38/00 (2013.01); A61K 2039/522 (2013.01); C07K 14/325 (2013.01); C12N 15/86 (2013.01);
Abstract

The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.

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