The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2018
Filed:
Jan. 29, 2016
Chungbuk National University Industry-academic Cooperation Foundation, Chungcheongbuk-do, KR;
Korea Institute of Science and Technology, Seoul, KR;
Hong-jun Lee, Gyeonggi-do, KR;
Sang-Hoon Cha, Chungcheongbuk-do, KR;
Hong-Jun Lee, Gyeonggi-do, KR;
Nakwon Choi, Seoul, KR;
Hong-Nam Kim, Seoul, KR;
Abstract
Provided are a neurovascular unit (NVU)-on-a-chip and a method of fabricating the same, which 3-dimensionally integrates various human brain cells in a microfluidic platform by using a brain cell co-culture technique so as to simulate a similar environment to the human brain in vitro. The NVU-on-a-chip includes an extracellular matrix (ECM) simulation material () in a gel state; and at least one channel () which passes through the ECM simulation material () and perfuses a culture medium, in which the ECM simulation material () contains a plurality of types of human brain cells on an outer side of the channel (), a brain microvessel endothelial cell lining () is formed on an inner side of the channel (), and the plurality of types of human brain cells and the brain microvessel endothelial cell lining () contact each other through the channel () to simulate a blood brain barrier (BBB) of a human brain and a neurovascular unit (NVU) of the human brain including the BBB.