The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2018
Filed:
Sep. 05, 2014
University of Miyazaki, Mayazaki-shi, Miyazaki, JP;
Fujita Health University, Toyoake-shi, Aichi, JP;
Perseus Proteomics Inc., Tokyo, JP;
Kazuhiro Morishita, Miyazaki-shi, JP;
Kazuko Kaneda, Miyazaki-shi, JP;
Yoshikazu Kurosawa, Toyoake-shi, JP;
Gene Kurosawa, Tokyo, JP;
Katsuyuki Mitomo, Tokyo, JP;
Katsushi Kouda, Tokyo, JP;
Yoshinori Ukai, Tokyo, JP;
UNIVERSITY OF MIYAZAKI, Miyazaki-shi, Miyazaki, JP;
FUJITA HEALTH UNIVERSITY, Toyoake-shi, Aichi, JP;
PERSEUS PROTEOMICS INC., Tokyo, JP;
Abstract
It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion.