The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2018
Filed:
Dec. 22, 2009
Liselotte Brix, Bagsværd, DK;
Henrik Pedersen, Lynge, DK;
Tina Jakobsen, Ballerup, DK;
Jørgen Schøller, Lyngby, DK;
Jesper Lohse, Coenhagen NV, DK;
Katja Brunstedt, Lyngby, DK;
Kivin Jacobsen, Hvalsø, DK;
Liselotte Brix, Bagsværd, DK;
Henrik Pedersen, Lynge, DK;
Tina Jakobsen, Ballerup, DK;
Jørgen Schøller, Lyngby, DK;
Jesper Lohse, Coenhagen NV, DK;
Katja Brunstedt, Lyngby, DK;
Kivin Jacobsen, Hvalsø, DK;
Dako Denmark A/S, Glostrup, DK;
Abstract
The present invention relates to a soluble negative control MHC multimer comprising a nonsense peptide that binds the MHC protein efficiently, but that does not support binding of the resultant MHC-peptide complex to the desired T Cell Receptor. The nonsense peptide is designed to i) have a length enabling binding to the MHC allele in question, ii) have appropriate amino acids at relevant anchor positions which anchor the nonsense peptide to the peptide-binding groove of the MHC, iii) have amino acids outside the anchor positions that do not support binding to a T Cell Receptor, and iv) have an amino acid sequence that is different from the linear sequence of any naturally occurring peptide.