The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 24, 2018

Filed:

Jun. 12, 2015
Applicant:

Cedars-sinai Medical Center, Los Angeles, CA (US);

Inventors:

Mouad Edderkaoui, Los Angeles, CA (US);

Ramachandran Murali, Swarthmore, PA (US);

Stephen Pandol, Los Angeles, CA (US);

Assignee:

CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 271/10 (2006.01); C07D 271/107 (2006.01); C07D 271/113 (2006.01); C07D 285/08 (2006.01); A61K 31/433 (2006.01); A61K 45/06 (2006.01); A61K 31/167 (2006.01); A61K 31/4245 (2006.01);
U.S. Cl.
CPC ...
C07D 285/08 (2013.01); A61K 31/167 (2013.01); A61K 31/4245 (2013.01); A61K 31/433 (2013.01); A61K 45/06 (2013.01); C07D 271/10 (2013.01); C07D 271/107 (2013.01); C07D 271/113 (2013.01);
Abstract

The invention describes compounds that inhibit both HDAC and GSK3β (i.e., HDAC/GSK3β dual inhibitors). The invention further describes compositions containing these HDAC/GSK3β dual inhibitors, as well as methods and kits using these HDAC/GSK3β dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3β to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3β. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.


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