The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2018
Filed:
May. 11, 2015
Applicant:
Tel Hashomer Medical Research Infrastructure and Services Ltd., Ramat Gan, IL;
Inventors:
Joab Chapman, Kiryat Ono, IL;
Efrat Shavit-Stein, Tel Aviv, IL;
Assignee:
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., Ramat Gan, IL;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/57 (2006.01); A61K 38/17 (2006.01); C07K 14/72 (2006.01); C07K 5/083 (2006.01); C07K 5/093 (2006.01); C07K 5/103 (2006.01); C07K 5/117 (2006.01); A61K 45/06 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1796 (2013.01); A61K 38/57 (2013.01); A61K 45/06 (2013.01); C07K 5/0806 (2013.01); C07K 5/0819 (2013.01); C07K 5/101 (2013.01); C07K 5/1024 (2013.01); C07K 14/723 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention is directed to a peptide conjugate comprising an alpha-amino protecting moiety, a peptide comprising the amino acid sequence at least 3 amino-acid long derived from the C'-terminus of PAR-1, or an active variant thereof and a protease-disabling moiety. The present invention is further directed to pharmaceutical compositions comprising the peptide conjugate and use thereof for treating diseases and disorder associated with excessive PAR-1 activity.