The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 24, 2018
Filed:
Oct. 30, 2015
Applicants:
University of Rochester, Rochester, NY (US);
Temple University—of the Commonwealth System of Higher Education, Philadelphia, PA (US);
Inventors:
Paul M. Dunman, Pittsford, NY (US);
Wayne Childers, New Hope, PA (US);
Assignees:
University of Rochester, Rochester, NY (US);
Temple University—Of the Commonwealth System of Higher Education, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/341 (2006.01); A61K 31/443 (2006.01); A61K 31/17 (2006.01); A61K 31/381 (2006.01); A61K 31/497 (2006.01); A61K 31/343 (2006.01); A61K 31/415 (2006.01); A61K 31/4409 (2006.01); A61K 31/4045 (2006.01); A61K 31/4184 (2006.01); A61K 31/47 (2006.01); A61K 31/44 (2006.01); A61K 45/06 (2006.01); A61K 31/351 (2006.01); A61K 47/10 (2017.01); A61K 9/06 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/341 (2013.01); A61K 9/0043 (2013.01); A61K 9/06 (2013.01); A61K 31/17 (2013.01); A61K 31/343 (2013.01); A61K 31/351 (2013.01); A61K 31/381 (2013.01); A61K 31/4045 (2013.01); A61K 31/415 (2013.01); A61K 31/4184 (2013.01); A61K 31/44 (2013.01); A61K 31/443 (2013.01); A61K 31/4409 (2013.01); A61K 31/47 (2013.01); A61K 31/497 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01);
Abstract
Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.