The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
Dec. 20, 2013
Hospital for Special Surgery, New York, NY (US);
University Health Network, Toronto, CA;
Carl Blobel, New York, NY (US);
Thorsten Maretzky, New York, NY (US);
David McIlwain, Toronto, CA;
Tak Wah Mak, Toronto, CA;
Hospital for Special Surgery, New York, NY (US);
University Health Network, Toronto, CA;
Abstract
Disclosed are methods for treating a subject with an EGFR dependent pathology. The method comprises the step of administering to the subject an effective amount of an agent ('First Agent') that decreases the biological activity of iRhom1 and an effective amount of an agent ('Second Agent') that decreases the biological activity of iRhom2. Alternatively, the method comprises the step of administering to the subject an effective amount of an agent (“First Agent”) that modulates formation of a complex between iRhom 1 and TACE and an effective amount of an agent (“Second Agent”) that modulates formation of a complex between TACE and iRhom2. Also disclosed are assays for identifying such agents.