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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10024826 B1

PDFFull Text
Date of Patent:
Jul. 17, 2018

Filed:

Aug. 22, 2012

Analysis of dried blood spot samples in a microfluidic system with dilution of extracted samples

Applicants:

James P. Murphy, Franklin, MA (US);

Michael J. Tomany, Thompson, CT (US);

Joseph D. Michienzi, Plainville, MA (US);

Paul Rainville, Princeton, MA (US);

Robert S. Plumb, Milford, MA (US);

Geoff C. Gerhardt, Millbury, MA (US);

Moon Chul Jung, Arlington, MA (US);

Inventors:

James P. Murphy, Franklin, MA (US);

Michael J. Tomany, Thompson, CT (US);

Joseph D. Michienzi, Plainville, MA (US);

Paul Rainville, Princeton, MA (US);

Robert S. Plumb, Milford, MA (US);

Geoff C. Gerhardt, Millbury, MA (US);

Moon Chul Jung, Arlington, MA (US);

Assignee:

WATERS TECHNOLOGIES CORPORATION, Milford, MA (US);

Attorney:

Schmeiser, Olsen & Watts LLP

Primary Examiner:

John Fitzgerald

Assistant Examiner:

Rodney T Frank

Int. Cl.
CPC ...
G01N 30/06 (2006.01); G01N 30/16 (2006.01); B01L 3/00 (2006.01); G01N 30/88 (2006.01); G01N 33/49 (2006.01); G01N 30/60 (2006.01); G01N 30/00 (2006.01); G01N 1/38 (2006.01);
U.S. Cl.
CPC ...
G01N 30/06 (2013.01); B01L 3/502715 (2013.01); G01N 30/16 (2013.01); G01N 30/88 (2013.01); G01N 33/49 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0874 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/1827 (2013.01); G01N 30/6095 (2013.01); G01N 2001/383 (2013.01); G01N 2030/009 (2013.01); G01N 2030/062 (2013.01);
Abstract

An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column.

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