The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
May. 22, 2015
Applicant:
Baylor Research Institute, Dallas, TX (US);
Inventors:
Anna Karolina Palucka, Avon, CT (US);
Jacques F Banchereau, Montclair, NJ (US);
Lee Roberts, Cordova, TN (US);
Assignee:
Baylor Research Institute, Dallas, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 35/15 (2015.01); C12N 5/0784 (2010.01); A61K 45/06 (2006.01); A61K 38/20 (2006.01); A61K 31/337 (2006.01); A61K 31/675 (2006.01); A61K 31/704 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0639 (2013.01); A61K 31/337 (2013.01); A61K 31/675 (2013.01); A61K 31/704 (2013.01); A61K 35/15 (2013.01); A61K 38/2006 (2013.01); A61K 39/0011 (2013.01); A61K 45/06 (2013.01); A61K 2039/5154 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/545 (2013.01); A61K 2039/6006 (2013.01); C12N 2501/22 (2013.01); C12N 2501/2304 (2013.01);
Abstract
Disclosed are compositions and methods for treatment of breast cancer. Disclosed methods and compositions include dendritic cells loaded with cyclin B1 and WT-1 peptide antigens for immunotherapy. These dendritic cell vaccines are administered alone or in combination with other cancer therapies to improve outcomes. Disclosed methods also involve the use of therapeutic agents, such as anakinra, that block the IL-1 inflammation pathway. These agents are used in combination with chemotherapy and/or immunotherapy in treating breast cancer.