The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
Mar. 10, 2015
Contipro A.s., Dolni Dobrouc, CZ;
Radovan Buffa, Humenne, SK;
Ivana Basarabova, Medzilaborce, SK;
Kristina Nesporova, Brno, CZ;
Tereza Ehlova, Dobruska, CZ;
Ondrej Kotland, Predmerice nad Labem, CZ;
Petra Sedova, Ceska Trebova, CZ;
Leos Hromek, Medlesice, CZ;
Vladimir Velebny, Zamberk, CZ;
Contipro a.s., Dolni Dobrouc, CZ;
Abstract
The invention relates to conjugates of hyaluronic acid oligomer according to the general formulae I, II III or IV, or a salt thereof, the method of preparation thereof and use thereof, where the oligomer is bonded to the respective substrate by its ending anomeric center via a bi-functional amino linker by means of an amino or imino bond. This type of conjugates allows releasing oligomers in their native form. The prepared systems exhibited an enhanced biological activity against selected lines of cancer cells.