The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
Feb. 04, 2015
Monash University, Clayton, Victoria, AU;
Memorial Sloan-kettering Cancer Centre, New York, NY (US);
Ludwig Institute for Cancer Research Ltd, New York, NY (US);
Beate Lackmann, St. Andrews Beach, AU;
Martin Lackmann, St Andrews Beach, AU;
Peter W. Janes, Hawthorn, AU;
Lakmali Atapattu Mudiyanselage, Hughesdale, AU;
Andrew M. Scott, Kew East, AU;
Dimitar B. Nikolov, New York, NY (US);
Nayanendu Saha, Jackson Heights, NY (US);
Monash University, Victoria, AU;
Memorial Sloan-Kettering Cancer Centre, New York, NY (US);
Ludwig Institute for Cancer Research Ltd., New York, NY (US);
Abstract
Expression of proteolytically active, high molecular weight ADAM protease is relatively increased in tumor cells that also express the putative tumor stem cell marker CD133. An antibody or antibody fragment such as 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight ADAM10 protease to thereby detect tumor cells and also as a therapeutic agent for treating cancers, tumors and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumor, renal tumor, prostate cancer, sarcoma and/or melanoma.