The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
Jun. 24, 2014
Applicant:
Board of Regents of the University of Nebraska, Lincoln, NE (US);
Inventors:
Michael Anthony Hollingsworth, Omaha, NE (US);
Prakash Radhakrishnan, Omaha, NE (US);
Assignee:
Board of Regents of the University of Nebraska, Lincoln, NE (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/30 (2006.01); A61K 39/395 (2006.01); A61K 31/7068 (2006.01); A61K 31/519 (2006.01); A61K 31/513 (2006.01); A61K 31/4745 (2006.01); A61K 31/282 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/3092 (2013.01); A61K 31/282 (2013.01); A61K 31/4745 (2013.01); A61K 31/513 (2013.01); A61K 31/519 (2013.01); A61K 31/7068 (2013.01); A61K 39/39558 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01);
Abstract
The present disclosure relates to a method of inhibiting tumor growth. More specifically, the present disclosure relates to the use of monoclonal antibodies for targeting truncated O-glycans on glycoproteins to inhibit activation of pro-survival ceil signaling pathways, to inhibit tumor growth. For example, monoclonal antibody AR9.6 may be used to target truncated O-glycans on the MUC16 glycoprotein, thereby inhibiting the phosphatidyiinositol 3-kinase/Akt (Pi3K/Akt) signaling pathway.