The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
Mar. 13, 2014
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Junfen Ma, Thousand Oaks, CA (US);
Xiaoyang Zhao, Moorpark, CA (US);
Brian Williamson, Camarillo, CA (US);
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/20 (2006.01); C07K 16/24 (2006.01); C07K 19/00 (2006.01); C07K 1/16 (2006.01);
U.S. Cl.
CPC ...
C07K 1/20 (2013.01); C07K 16/241 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01);
Abstract
Disclosed are methods of purifying a protein sample. More specifically, provide are methods of removing or reducing the amount of high molecular weight species and/or high mannose species from a protein sample using a mixed mode chromatography step and a hydrophobic interaction chromatography step.