The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
Sep. 21, 2016
The Regents of the University of California, Oakland, CA (US);
Vybyl Holdings, Inc., Woodridge, IL (US);
Cassandra E. Callmann, San Diego, CA (US);
Matthew P. Thompson, San Diego, CA (US);
Nathan C. Gianneschi, San Diego, CA (US);
Clare L. M. LeGuyader, San Diego, CA (US);
Paul A. Bertin, Western Springs, IL (US);
The Regents of the University of California, Oakland, CA (US);
Vybyl Holdings, Inc., Woodridge, IL (US);
Abstract
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.