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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10023551 B1

PDFFull Text
Expired
Date of Patent:
Jul. 17, 2018

Filed:

May. 12, 2016

Glutathione-cleavable prodrug and methods of use thereof

Applicant:

Georgetown University, Washington, DC (US);

Inventors:

Milton L. Brown, Brookeville, MD (US);

Yali Kong, Fairfax, VA (US);

Jacqueline Smith, Bowie, MD (US);

Kan Wang, Gaithersburg, MD (US);

Shujie Hou, Gaithersburg, MD (US);

Assignee:

Georgetown University, Washington, DC (US);

Attorney:

Kilpatrick Townsend & Stockton, LLP

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 311/58 (2006.01); C07D 311/02 (2006.01); A61P 35/00 (2006.01); G01N 21/64 (2006.01); A61K 47/69 (2017.01); C07C 321/14 (2006.01); C07C 69/017 (2006.01); C07C 69/003 (2006.01); C07C 271/28 (2006.01);
U.S. Cl.
CPC ...
C07D 311/02 (2013.01); A61K 47/6957 (2017.08); A61P 35/00 (2018.01); C07C 69/003 (2013.01); C07C 69/017 (2013.01); C07C 271/28 (2013.01); C07C 321/14 (2013.01); C07D 311/58 (2013.01); G01N 21/64 (2013.01);
Abstract

A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

Find Patent Forward Citations

Brown, Milton. (2018). Glutathione-cleavable prodrug and methods of use thereof (U.S. Patent No. 10023551). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10023551

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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