The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 17, 2018

Filed:

Dec. 10, 2014
Applicant:

Bayer Pharma Aktiengesellschaft, Berlin, DE;

Inventors:

Hans-Georg Lerchen, Leverkusen, DE;

Sven Wittrock, Lyons, FR;

Nils Griebenow, Dormagen, DE;

Beatrix Stelte-Ludwig, Wülfrath, DE;

Anette Sommer, Berlin, DE;

Sandra Berndt, Hohen Neuendorf, DE;

Christoph Mahlert, Wuppertal, DE;

Mario Lobell, Wuppertal, DE;

Carsten Terjung, Bochum, DE;

Simone Greven, Dormagen, DE;

Yolanda Cancho Grande, Leverkusen, DE;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/48 (2006.01); C07D 403/12 (2006.01); C07D 231/12 (2006.01); C07D 233/64 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 207/335 (2006.01); C07C 53/18 (2006.01); C07D 207/337 (2006.01); C07K 5/062 (2006.01); C07K 5/107 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
A61K 47/48561 (2013.01); A61K 47/6803 (2017.08); A61K 47/6811 (2017.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); C07C 53/18 (2013.01); C07D 207/335 (2013.01); C07D 207/337 (2013.01); C07D 231/12 (2013.01); C07D 233/64 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07K 5/06052 (2013.01); C07K 5/1016 (2013.01); C07K 16/2863 (2013.01); C07K 16/2875 (2013.01); C07K 16/32 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/75 (2013.01); C07K 2317/92 (2013.01);
Abstract

The present application relates to novel antibody drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.


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