The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 17, 2018

Filed:

Nov. 02, 2015
Applicants:

Massachusetts Eye and Ear Infirmary, Boston, MA (US);

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Demetrios G. Vavvas, Boston, MA (US);

Joan W. Miller, Winchester, MA (US);

Larry Benowitz, Newton, MA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/05 (2006.01); A61K 45/06 (2006.01); A61K 31/27 (2006.01); A61K 31/4178 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/05 (2013.01); A61K 31/27 (2013.01); A61K 31/4178 (2013.01); A61K 38/005 (2013.01); A61K 45/06 (2013.01);
Abstract

Provided are methods for promoting axon regeneration of a Central Nervous System (CNS) neuron and promoting nerve function following injury to a CNS neuron, for example, brain and/or spinal cord injury. Axon regeneration in a CNS neuron or nerve function following injury to a CNS neuron can be promoted by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject suffering from a CNS disorder, wherein a symptom of the CNS disorder is axon degeneration.


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