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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10022352 B1

PDFFull Text
Date of Patent:
Jul. 17, 2018

Filed:

Mar. 23, 2016

Modulators of atp-binding cassette transporters

Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Sara Sabina Hadida Ruah, La Jolla, CA (US);

Peter Diederik Jan Grootenhuis, San Diego, CA (US);

Fredrick F. Van Goor, San Diego, CA (US);

Jinglan Zhou, San Diego, CA (US);

Brian Richard Bear, Carlsbad, CA (US);

Mark Thomas Miller, San Diego, CA (US);

Jason McCartney, Cardiff by the Sea, CA (US);

Mehdi Michel Djamel Numa, San Diego, CA (US);

Assignee:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Attorney:

Finnegan, Henderson, Farabow, Garrett & Dunner, LLP

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
A61K 31/405 (2006.01); A61K 31/404 (2006.01); A61K 45/06 (2006.01); A61K 9/28 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); A61K 31/4045 (2006.01); A61K 31/407 (2006.01); A61K 31/41 (2006.01); A61K 31/4184 (2006.01); A61K 31/4192 (2006.01); A61K 31/454 (2006.01); A61K 31/5377 (2006.01); C07D 233/64 (2006.01); C07D 405/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 209/08 (2006.01); G01N 33/50 (2006.01); A61K 31/47 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 31/404 (2013.01); A61K 9/28 (2013.01); A61K 31/405 (2013.01); A61K 31/407 (2013.01); A61K 31/4045 (2013.01); A61K 31/41 (2013.01); A61K 31/4184 (2013.01); A61K 31/4192 (2013.01); A61K 31/454 (2013.01); A61K 31/47 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 209/08 (2013.01); C07D 233/64 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); G01N 33/5035 (2013.01); G01N 33/6893 (2013.01); G01N 2333/705 (2013.01); G01N 2800/382 (2013.01);
Abstract

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

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