The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 2018
Filed:
Jul. 17, 2013
Onyx Therapeutics, Inc., South San Francisco, CA (US);
Katherine A. Chu, San Francisco, CA (US);
Elena T. Chan, San Mateo, CA (US);
Ying Fang, Saratoga, CA (US);
Mouhannad Jamaa, Foster City, CA (US);
Christopher Justin Kirk, Milbrae, CA (US);
Tony Muchamuel, Boulder Creek, CA (US);
Zhengping Wang, San Mateo, CA (US);
Jing Jiang, San Jose, CA (US);
Jeffrey Joseph Jones, Redwood City, CA (US);
Onyx Therapeutics, Inc., Thousand Oaks, CA (US);
Abstract
Liposomal compositions comprising peptide epoxyketone compounds are described, as well as methods of making and using such liposomal compositions. These liposomal compositions enhance the therapeutic window of peptide epoxyketone compounds by improving in vivo half-life relative to non-liposomal compositions comprising peptide epoxyketone compounds, providing desirable pharmacodynamic profiles, and providing anti-tumor activity in a human tumor xenograft model, greater than or equal to non-liposomal compositions comprising peptide epoxyketone compounds. Further, experiments performed in support of the present invention demonstrated improved tolerability of liposomal compositions comprising peptide epoxyketone compounds.