The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Mar. 12, 2013
Applicant:
Duke University, Durham, NC (US);
Inventors:
Thomas F. Tedder, Durham, NC (US);
Ayumi Yoshizaki, Durham, NC (US);
Tomomitsu Miyagaki, Durham, NC (US);
Evgueni Kountikov, Durham, NC (US);
Jonathan C. Poe, Durham, NC (US);
Assignee:
DUKE UNIVERSITY, Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/02 (2006.01); C12N 5/00 (2006.01); C12N 5/0781 (2010.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0635 (2013.01); A61K 35/17 (2013.01); C12N 2501/15 (2013.01); C12N 2501/231 (2013.01); C12N 2501/2304 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/2312 (2013.01); C12N 2501/2321 (2013.01); C12N 2501/24 (2013.01); C12N 2501/52 (2013.01); C12N 2501/599 (2013.01);
Abstract
Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.