The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Feb. 27, 2013
Korea Advanced Institute of Science and Technology, Daejeon, KR;
The Industry & Academic Cooperation IN Chungnam National University (Iac), Daejeon, KR;
Korea Basic Science Institute, Daejeon, KR;
Hak-Sung Kim, Daejeon, KR;
Joong-Jae Lee, Daejeon, KR;
Jung Min Choi, Daejeon, KR;
Eun-Kyeong Jo, Daejeon, KR;
Chul-Su Yang, Daejeon, KR;
Hae-Kap Cheong, Chungcheongbuk-do, KR;
Hyun Jung Kim, Chungcheongbuk-do, KR;
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, Daejeon, KR;
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC), Daejeon, KR;
KOREA BASIC SCIENCE INSTITUTE, Daejeon, KR;
Abstract
The present invention relates to an repebody capable of binding specifically to interleukin-6 (IL-6) to inhibit the biological activity of IL-6, a polynucleotide encoding the repebody, a vector comprising the polynucleotide, a recombinant microorganism having introduced therein the polynucleotide or the vector, a method of producing the repebody using the recombinant microorganism, a composition for preventing or treating cancer, which comprises the repebody, and a method for preventing or treating cancer, which comprises administering the composition for preventing or treating cancer, which comprises the repebody. The repebody of the present invention significantly reduces the activity of signal transduction and activator of transciption3 (STAT3) and the concentration of interleukin-6, and thus can be widely used as an agent for preventing or treating IL-6-related diseases.