The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Aug. 30, 2012
Michael Niederweis, Homewood, AL (US);
Olga Danilchanka, Birmingham, AL (US);
Michael Niederweis, Homewood, AL (US);
Olga Danilchanka, Birmingham, AL (US);
The UAB Research Foundation, Birmingham, AL (US);
Abstract
Provided herein are isolated polypeptides comprising the amino-terminal domain ofporin A (MtpA), wherein the polypeptide is a porin monomer. Also provided are isolated polypeptides comprising the carboxy-terminal domain ofporin A, wherein the polypeptide is a toxin. Also provided are methods of treating or preventing a(Mtb) infection in a subject with or at risk of developing a Mtb infection. Further provided are chimeric porin polypeptides comprising a first polypeptide comprising an amino-terminal domain ofporin and a second polypeptide comprising an antigen and the use the chimeric porin polypeptides in methods of eliciting an immune response in a subject.