The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Jun. 08, 2015
Applicant:
Naval Medical Research Center, Silver Spring, MD (US);
Inventor:
Stephen J. Savarino, Kensington, MD (US);
Assignee:
Naval Medical Research Center, Silver Spring, MD (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61K 39/108 (2006.01); A61K 39/02 (2006.01); A61K 38/00 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); C07K 5/00 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C12P 21/04 (2006.01); C07K 14/245 (2006.01); C07K 16/12 (2006.01);
U.S. Cl.
CPC ...
C07K 14/245 (2013.01); A61K 39/0258 (2013.01); C07K 16/1232 (2013.01); A61K 38/00 (2013.01); A61K 2039/523 (2013.01); A61K 2039/545 (2013.01); C07K 2317/55 (2013.01); C07K 2319/00 (2013.01); C07K 2319/35 (2013.01);
Abstract
The inventive subject matter relates to the methods for the induction of immunity and prevention of diarrhea resulting from. The inventive subject matter also relates to the useadhesins as immunogens and to the construction of conformationally stability and protease resistantadhesin constructs useful for inducing immunity topathogenic bacteria. The methods provide for the induction of B-cell mediated immunity and for the induction of antibody capable of inhibiting the adherence and colonization of, including enterotoxigenic, to human cells.