The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Mar. 11, 2016
Applicant:
California Institute of Technology, Pasadena, CA (US);
Inventors:
Ryan K. Henning, Pasadena, CA (US);
Ashwin N. Ram, Pasadena, CA (US);
Samir Das, Pasadena, CA (US);
Arundhati Nag, Pasadena, CA (US);
James R. Heath, South Pasadena, CA (US);
Assignee:
California Institute of Technology, Pasadena, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61P 35/00 (2006.01); C07K 7/64 (2006.01); G01N 33/574 (2006.01); C07K 14/82 (2006.01); C07K 7/06 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); C07K 7/06 (2013.01); C07K 14/82 (2013.01); G01N 33/5748 (2013.01); A61K 38/00 (2013.01); G01N 2333/82 (2013.01); G01N 2333/914 (2013.01); G01N 2500/04 (2013.01);
Abstract
Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.