The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Apr. 02, 2015
Janssen Pharmaceutica NV, Beerse, BE;
Gaston Stanislas Marcella Diels, Beerse, BE;
Bruno Schoentjes, Ville d'Avray, FR;
Matthias Luc Aime Versele, Leuven, BE;
Didier Jean-Claude Berthelot, La Neuville Chant d'Oisel, FR;
Marc Willems, Vosselaar, BE;
Marcel Viellevoye, Breda, NL;
Werner Constant Johan Embrechts, Beerse, BE;
Berthold Wroblowski, Vosselaar, BE;
Lieven Meerpoel, Beerse, BE;
Janssen Pharmaceutica NV, Beerse, BE;
Abstract
The present invention relates to substituted macrocylic pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.