The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Jul. 19, 2017
Applicant:
Proteostasis Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Cecilia M. Bastos, South Grafton, MA (US);
Benito Munoz, Newtonville, MA (US);
Bradley Tait, Malden, MA (US);
Assignee:
Proteostasis Therapeutics, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/12 (2006.01); C07D 417/12 (2006.01); A61K 31/422 (2006.01); A61K 31/433 (2006.01); A61K 45/06 (2006.01); A61K 31/506 (2006.01); A61K 31/4439 (2006.01);
U.S. Cl.
CPC ...
C07D 413/12 (2013.01); A61K 31/422 (2013.01); A61K 31/433 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07D 417/12 (2013.01);
Abstract
The disclosure encompasses compounds having e.g., Formula (Ia) or (Ib), compositions thereof, and methods of modulating CFTR activity. The disclosure also encompasses methods of treating a condition associated with CFTR activity or condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a compound of Formula (I) or (Ib).