The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Feb. 10, 2015
Universitâ Degli Studi Di Genova, Genoa, IT;
The Trustees of Columbia University, New York, NY (US);
Maastricht University, Maastricht, NL;
Olga Bruno, Genoa, IT;
Chiara Brullo, Genoa, IT;
Alessia Romussi, Genoa, IT;
Ernesto Fedele, Genoa, IT;
Roberta Ricciarelli, Genoa, IT;
Ottavio Arancio, New York, NY (US);
Jos Prickaerts, Maastricht, NL;
UNIVERSITA DEGLI STUDI DI GENOVA, Genoa, IT;
THE TRUSTEES OF COLUMBIA UNIVERSITY, New York, NY (US);
MAASTRICHT UNIVERSITY, Maastricht, NL;
Abstract
Compounds of formula (I), wherein Z=cyclopentyl. cyclopropylmethyl, —CH; R'═—CH, CHF, X=formula (II) (III) (IV) (V) Y=—CO; —C═O(CH), —CH(OH)—CH, —CH—C═O, —CH—CH—C═O; —CH—CH(OH)—CH, —CH—CH(OCOR)—CHNR═ —N(CH—CHOH), formula (VI) (VII) (VIII) (IX) (X) (XI) R=optionally substituted C-Calkyl, optionally substituted aryl; optionally substituted aralkyl, preferably C-Calkyl, more preferably CH; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; these compounds have a PDE4D inhibiting activity and can be used as a medicament for treating dementia, in particular Alzheimer disease, and for improving memory.