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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10016499 B1

PDFFull Text
Date of Patent:
Jul. 10, 2018

Filed:

Apr. 13, 2016

Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same

Applicant:

Northwestern University, Evanston, IL (US);

Inventors:

Phillip B. Messersmith, Clarendon Hills, IL (US);

Kvar C. L. Black, Evanston, IL (US);

Ji Yi, Evanston, IL (US);

Jose G. Rivera, Waukegan, IL (US);

Assignee:

Northwestern University, Evanston, IL (US);

Attorney:

Quarles and Brady, LLP

Primary Examiner:

Brian Gangle

Assistant Examiner:

Andrea K McCollum

Int. Cl.
CPC ...
A61K 41/00 (2006.01); A61K 49/18 (2006.01); A61N 5/06 (2006.01); C07K 16/30 (2006.01); G01N 33/543 (2006.01); G01N 33/553 (2006.01); A61K 9/16 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); B82Y 5/00 (2011.01); C07K 16/00 (2006.01); G01N 21/47 (2006.01); G01N 21/552 (2014.01); A61K 31/69 (2006.01); A61K 33/00 (2006.01); B82Y 40/00 (2011.01); A61K 45/06 (2006.01); A61K 33/26 (2006.01); A61K 33/38 (2006.01); A61K 9/51 (2006.01); A61K 39/395 (2006.01); A61K 39/40 (2006.01); G01N 33/58 (2006.01); C07K 16/28 (2006.01); A61K 47/69 (2017.01); B82Y 15/00 (2011.01);
U.S. Cl.
CPC ...
A61K 41/0052 (2013.01); A61K 9/0092 (2013.01); A61K 9/1611 (2013.01); A61K 9/1641 (2013.01); A61K 9/1676 (2013.01); A61K 9/1682 (2013.01); A61K 9/5094 (2013.01); A61K 9/51 (2013.01); A61K 31/69 (2013.01); A61K 33/00 (2013.01); A61K 33/26 (2013.01); A61K 33/38 (2013.01); A61K 39/39558 (2013.01); A61K 39/40 (2013.01); A61K 41/0057 (2013.01); A61K 45/06 (2013.01); A61K 47/6923 (2017.08); A61K 49/1857 (2013.01); A61K 49/1875 (2013.01); A61N 5/062 (2013.01); B82Y 5/00 (2013.01); B82Y 40/00 (2013.01); C07K 16/00 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); G01N 21/4795 (2013.01); G01N 21/554 (2013.01); G01N 33/54346 (2013.01); G01N 33/553 (2013.01); G01N 33/587 (2013.01); B82Y 15/00 (2013.01);
Abstract

The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.

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