The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Apr. 13, 2016
Applicant:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Inventors:
Vinod Labhasetwar, Cleveland, OH (US);
Jaspreet K. Vasir, Cleveland, OH (US);
Maram K. Reddy, Cleveland, OH (US);
Assignee:
The Cleveland Clinic Foundation, Cleveland, OH (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/44 (2006.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61F 2/82 (2013.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01); A61L 29/04 (2006.01); A61L 29/16 (2006.01); A61L 31/04 (2006.01); A61L 31/16 (2006.01); A61M 25/10 (2013.01);
U.S. Cl.
CPC ...
A61K 38/44 (2013.01); A61F 2/82 (2013.01); A61K 9/0019 (2013.01); A61K 9/4866 (2013.01); A61K 9/5031 (2013.01); A61K 9/5153 (2013.01); A61L 29/048 (2013.01); A61L 29/16 (2013.01); A61L 31/047 (2013.01); A61L 31/16 (2013.01); A61M 25/10 (2013.01); C12Y 114/13039 (2013.01); A61F 2210/0076 (2013.01); A61F 2310/0097 (2013.01); A61L 2300/254 (2013.01); A61L 2300/412 (2013.01); A61L 2300/606 (2013.01); A61M 2025/105 (2013.01);
Abstract
A sustained-release composition for stimulating endothelial cell growth including a nitric oxide synthase within a nanoparticle comprising a biocompatible polymer is described. The sustained-release composition can be administered as part of a pharmaceutical composition, or can be coated on a medical device. The nitric oxide synthase-containing nanoparticles can be used in a method of inducing endothelium formation in a blood vessel.