The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 10, 2018

Filed:

Aug. 01, 2014
Applicant:

Wake Forest University Health Sciences, Winston-Salem, NC (US);

Inventors:

Sean V. Murphy, Winston-Salem, NC (US);

Aleksander Skardal, Winston-Salem, NC (US);

Anthony Atala, Winston-Salem, NC (US);

Assignee:

Wake Forest University Health Sciences, Winston-Salem, NC (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/50 (2015.01); A61K 47/42 (2017.01); A61L 27/52 (2006.01); A61L 27/34 (2006.01); A61L 27/48 (2006.01); A61L 15/40 (2006.01); A61L 26/00 (2006.01); A61K 47/36 (2006.01); C12N 5/00 (2006.01); A61L 27/36 (2006.01);
U.S. Cl.
CPC ...
A61K 35/50 (2013.01); A61K 47/36 (2013.01); A61K 47/42 (2013.01); A61L 15/40 (2013.01); A61L 26/0057 (2013.01); A61L 26/0076 (2013.01); A61L 27/34 (2013.01); A61L 27/3604 (2013.01); A61L 27/3683 (2013.01); A61L 27/48 (2013.01); A61L 27/52 (2013.01); C12N 5/0068 (2013.01); A61L 2430/40 (2013.01); C12N 2533/92 (2013.01);
Abstract

The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.


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