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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10016439 B1

PDFFull Text
Date of Patent:
Jul. 10, 2018

Filed:

Jan. 30, 2015

Fused imidazole compounds

Applicant:

Ono Pharmaceutical Co., Ltd., Osaka-shi, Osaka, JP;

Inventors:

Tetsuji Saito, Osaka, JP;

Masato Higashino, Osaka, JP;

Soichi Kawaharada, Osaka, JP;

Arwel Lewis, Essex, GB;

Mark Stuart Chambers, Essex, GB;

Alastair Rae, Essex, GB;

Kim Louise Hirst, Essex, GB;

Charles David Hartley, Essex, GB;

Assignee:

ONO PHARMACEUTICAL CO., LTD., Osaka-Shi, JP;

Attorney:

Foley & Lardner LLP

Primary Examiner:

Karl J Puttlitz

Int. Cl.
CPC ...
A61K 31/5383 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 31/517 (2006.01); A61K 31/538 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01); C07D 473/32 (2006.01); C07D 498/04 (2006.01); C07D 519/00 (2006.01); A61K 31/4184 (2006.01); A61K 31/423 (2006.01); A61K 31/437 (2006.01); A61K 31/4985 (2006.01); A61K 45/06 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5383 (2013.01); A61K 31/4184 (2013.01); A61K 31/423 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/4985 (2013.01); A61K 31/517 (2013.01); A61K 31/538 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 473/32 (2013.01); C07D 487/04 (2013.01); C07D 498/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides compounds represented by formula (I), pharmaceutically acceptable salts thereof, N-oxides thereof, solvates thereof or prodrugs thereof (wherein the characters are as defined in the description). The compounds represented by formula (I) have affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 (GABAα5) and act as GABAα5 negative allosteric modulators (GABAα5 NAM), so that they are useful in the prevention and/or treatment of diseases which are related to the GABAα5 such as Alzheimer's disease.

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