The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 10, 2018
Filed:
Aug. 17, 2015
Alkermes Pharma Ireland Limited, Dublin, IE;
Philip Cresswell, Athlone, IE;
Sara Montminy Paquette, Hudson, MA (US);
Magali Hickey, Westwood, MA (US);
Kristopher Perkin, Athlone, IE;
Greg Smith, Norton, MA (US);
Elaine Liversidge, Charlestown, MA (US);
Brian Steinberg, Arlington, MA (US);
David Manser, Keenagh, IE;
Ryan Turncliff, Ashland, MA (US);
Michael Palmieri, Jr., Hopkinton, MA (US);
Tarek Zeidan, Waltham, MA (US);
Ethan P. Cash, Sudbury, MA (US);
Marjie L. Hard, Lexington, MA (US);
ALKERMES PHARMA IRELAND LIMITED, Dublin, IE;
Abstract
Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm and (b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilization of the aripiprazole prodrug. The surface stabilizer to prodrug ratio provides the optimal quantity of free surface stabilizer for the purposes of producing a lead-in formulation. Also described are methods of treatment using the aforementioned composition.