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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10016410 B1

PDFFull Text
Date of Patent:
Jul. 10, 2018

Filed:

Nov. 14, 2016

Tetrahydroisoquinolin-1-one derivative or salt thereof

Applicant:

Seldar Pharma Inc., Bridgewater, NJ (US);

Inventors:

Hiroyuki Hisamichi, Tokyo, JP;

Itsuro Shimada, Tokyo, JP;

Tsukasa Ishihara, Tokyo, JP;

Tomofumi Takuwa, Tokyo, JP;

Takafumi Shimizu, Tokyo, JP;

Noriko Ishikawa, Tokyo, JP;

Kyoichi Maeno, Tokyo, JP;

Norio Seki, Tokyo, JP;

Assignee:

Seldar Pharma Inc., Bridgewater, NJ (US);

Attorney:

Foley & Lardner LLP

Primary Examiner:

Yong S Chong

Int. Cl.
CPC ...
A61K 31/435 (2006.01); A61K 31/439 (2006.01); A61K 31/445 (2006.01); A61K 31/4725 (2006.01); C07D 217/26 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/04 (2006.01); C07D 405/06 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 453/02 (2006.01); C07D 471/04 (2006.01); A61K 31/472 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/695 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4725 (2013.01); A61K 31/435 (2013.01); A61K 31/439 (2013.01); A61K 31/445 (2013.01); A61K 31/472 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/695 (2013.01); C07D 217/26 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/04 (2013.01); C07D 405/06 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 453/02 (2013.01); C07D 471/04 (2013.01);
Abstract

To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

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