The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Mar. 31, 2006
Applicants:
Tomoyuki Igawa, Shizuoka, JP;
Hiroyuki Tsunoda, Shizuoka, JP;
Inventors:
Tomoyuki Igawa, Shizuoka, JP;
Hiroyuki Tsunoda, Shizuoka, JP;
Assignee:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C12P 21/02 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); C07K 16/18 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01);
Abstract
In the course of the present invention, it was discovered that one could regulate association between polypeptides by modifying amino acid residues that form the interface during the association to amino acids carrying the same type of charge. In this context, the present invention enables efficient formation of heterologous molecules. For example, the present invention can be suitably applied to the preparation of bispecific antibodies.