The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 03, 2018
Filed:
Apr. 11, 2016
Applicant:
William Marsh Rice University, Houston, TX (US);
Inventors:
Ka-Yiu San, Houston, TX (US);
Wei Li, Houston, TX (US);
Assignee:
William Marsh Rice University, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12P 7/64 (2006.01); C12P 7/62 (2006.01); C12N 9/00 (2006.01); C12N 9/02 (2006.01); C07H 21/04 (2006.01); C12N 9/04 (2006.01); C12N 9/16 (2006.01);
U.S. Cl.
CPC ...
C12P 7/6409 (2013.01); C12N 9/0006 (2013.01); C12N 9/16 (2013.01); C12Y 101/011 (2013.01); C12Y 101/0133 (2015.07); C12Y 301/02014 (2013.01); C12Y 101/01 (2013.01);
Abstract
The present disclosure relates to an engineered microbe capable of improved productivity of fatty acid or fatty acid derivative. An NAD-dependent 3-oxoacyl-ACP reductase or NAD-dependent 3-oxoacyl-CoA reductase replaces or supplements the native NADP-dependent 3-oxoacyl-ACP reductase so as to utilize the higher availability of NADrather than NADPin the cell. Higher production, yield and titer of fatty acids are therefore obtained. Such microbes can be combined with other mutations to further improve yield of fatty acids or fatty acid derivatives.